Affective Disorder Clinical Trials

65 recruitingLast updated: June 18, 2026

There are 65 actively recruiting affective disorder clinical trials across 16 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3. Top locations include Pittsburgh, Pennsylvania, United States, Belmont, Massachusetts, United States, San Diego, California, United States. Updated daily from ClinicalTrials.gov.


Affective Disorder Trials at a Glance

65 actively recruiting trials for affective disorder are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Not Applicable with 34 trials, with the heaviest enrollment activity in Pittsburgh, Belmont, and San Diego. Lead sponsors running affective disorder studies include Mclean Hospital, VA Office of Research and Development, and Deepak K. Sarpal, M.D..

Browse affective disorder trials by phase

Treatments under study

About Affective Disorder Clinical Trials

Looking for clinical trials for Affective Disorder? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Affective Disorder trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Affective Disorder clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 65 trials

Recruiting
Phase 4

A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

SchizophreniaMajor Depressive DisorderBipolar Disorder+2 more
Neurocrine Biosciences50 enrolled22 locationsNCT07105111
Recruiting
Phase 2

Neurotransmitters in Treatment Resistant Schizophrenia Patients With add-on Sodium Benzoate

SchizophreniaSchizo Affective DisorderSymptom, Cognitive
National Cheng-Kung University Hospital90 enrolled1 locationNCT06340789
Recruiting
Phase 4

Bazedoxifene -Treatment for Women With Schizophrenia

SchizophreniaSchizo Affective DisorderSchizophreniform Disorders
The Alfred160 enrolled1 locationNCT04113993
Recruiting
Not Applicable

Exploring the Feasibility of Transcranial Ultrasound Stimulation in the Treatment of Schizophrenia

Schizo Affective Disorder
Far Eastern Memorial Hospital80 enrolled1 locationNCT07621549
Recruiting
Phase 4

Metabolic Effects of Adjunctive Lumateperone Treatment in Clozapine-Treated Patients With Schizophrenia

SchizophreniaSchizo Affective Disorder
University of Massachusetts, Worcester50 enrolled1 locationNCT06174116
Recruiting
Phase 4

CLOZAPINE Response in Biotype-1

SchizophreniaSchizoaffective DisorderBipolar 1 Disorder
University of Texas Southwestern Medical Center524 enrolled5 locationsNCT04580134
Recruiting
Phase 2

Melatonin Versus Placebo for Bipolar Disorder

Bipolar Affective Disorder
Lars Vedel Kessing200 enrolled1 locationNCT07472075
Recruiting

Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients

Schizophrenia DisordersPersonality DisordersDepression Disorders+1 more
University of Edinburgh100 enrolled1 locationNCT07398365
Recruiting
Phase 4

Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

SchizophreniaSchizoaffective Disorder
New York State Psychiatric Institute280 enrolled7 locationsNCT05208190
Recruiting

Validation and Impact of Cardiorespiratory Fitness in Severe Mental Illness - the Heart in Mind Project

Bipolar Affective DisorderSevere Mental IllnessSchizophrenia Spectrum & Other Psychotic Disorders
Bjorn H. Ebdrup75 enrolled1 locationNCT06743711
Recruiting

Database Registry for Neural Network Biomarkers in Psychosis

SchizophreniaSchizoaffective Disorder
University of Texas Southwestern Medical Center1,000 enrolled1 locationNCT01409109
Recruiting
Not Applicable

Examining the Efficacy of a Virtual Reality Cognitive Remediation Program for People Living With Psychosis

SchizophreniaPsychotic DisordersSchizo Affective Disorder
The Royal Ottawa Mental Health Centre52 enrolled1 locationNCT05973110
Recruiting
Phase 1

Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder

SchizophreniaSchizo Affective DisorderBipolar Disorder I+2 more
BioXcel Therapeutics Inc140 enrolled5 locationsNCT05025605
Recruiting
Not Applicable

Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine

SchizophreniaSchizoaffective Disorder
Deepak K. Sarpal, M.D.30 enrolled1 locationNCT06003036
Recruiting
Phase 1Phase 2

Acetazolamide for Treatment Resistant Schizophrenia

SchizophreniaSchizo Affective Disorder
Vishwajit Nimgaonkar, MD PhD60 enrolled2 locationsNCT04887792
Recruiting
Phase 2

Synbiotic Compound to Reduce Symptoms of Schizophrenia

SchizophreniaSchizoaffective Disorder
Sheppard Pratt Health System68 enrolled1 locationNCT04226898
Recruiting

Brain Imaging of Cognition Inn Schizophrenia and Depression

Depression - Major Depressive DisorderSchizophrenia / Schizoaffective Disorder
The Royal Ottawa Mental Health Centre90 enrolled1 locationNCT04159662
Recruiting
Phase 1Phase 2

Cromoglicate Adjunctive Therapy for Outpatients With Schizophrenia

SchizophreniaSchizo Affective Disorder
Vishwajit Nimgaonkar, MD PhD160 enrolled1 locationNCT03794076
Recruiting
Not Applicable

Cerebellar Modulation of Cognition in Psychosis

SchizophreniaPsychosisSchizoaffective Disorder+1 more
Mclean Hospital95 enrolled2 locationsNCT06107764
Recruiting
Not Applicable

Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways

Schizo Affective DisorderSCHIZOPHRENIA 1 (Disorder)
Nathan Kline Institute for Psychiatric Research120 enrolled1 locationNCT07469384