Chronic rhinosinusitis Clinical Trials

56 recruitingLast updated: July 25, 2026

There are 56 actively recruiting chronic rhinosinusitis clinical trials across 35 countries. Studies span Not Applicable, Phase 3, Phase 2, Phase 4, Phase 1, Early Phase 1. Top locations include Chicago, Illinois, United States, Ghent, Belgium, Leuven, Belgium. Updated daily from ClinicalTrials.gov.


Chronic rhinosinusitis Trials at a Glance

56 actively recruiting trials for chronic rhinosinusitis are listed on ClinicalTrialsFinder across 6 cities in 35 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Chicago, Ghent, and Leuven. Lead sponsors running chronic rhinosinusitis studies include AstraZeneca, Sanofi, and Medical University of Vienna.

Browse chronic rhinosinusitis trials by phase

Treatments under study

About Chronic rhinosinusitis Clinical Trials

Looking for clinical trials for Chronic rhinosinusitis? There are currently 21 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic rhinosinusitis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic rhinosinusitis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 56 trials

Recruiting
Phase 1Phase 2

A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With or Without Comorbid Asthma

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Bambusa Therapeutics64 enrolled12 locationsNCT07436949
Recruiting

Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.

Smell LossChronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP)
Northwestern University30 enrolled1 locationNCT06892704
Recruiting

ReAl-woRld Evaluation of tEzepelumab for Chronic rhinoSinusitis With Nasal Polyps in Russia

AsthmaChronic Rhinosinusitis With Nasal Polyps (CRSwNP)
AstraZeneca110 enrolled11 locationsNCT07399665
Recruiting
Phase 3

A Study to Investigate NPS and Symptoms in Chinese Adult Participants With CRSwNP Initiating Treatment With Tezepelumab

Chronic Rhinosinusitis With Nasal Polyps
AstraZeneca230 enrolled33 locationsNCT07520162
Recruiting

A Study to Investigate the Clinical Outcome and Quality of Life in Chinese Post-operative CRSwNP Patients

Chronic Rhinosinusitis With Nasal Polyps
AstraZeneca200 enrolled18 locationsNCT07446738
Recruiting
Phase 3

A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Eli Lilly and Company510 enrolled202 locationsNCT06338995
Recruiting
Not Applicable

Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training

Chronic Rhinosinusitis (CRS)Smell Loss
The Cleveland Clinic52 enrolled1 locationNCT07681973
Recruiting
Not Applicable

Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis

Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Airiver Medical, Inc.300 enrolled8 locationsNCT07290140
Recruiting
Not Applicable

3D Printing to Improve Nasal Irrigation Outcome

Chronic Rhinosinusitis With Nasal PolypsChronic Rhinosinusitis Without Nasal Polyps
Ohio State University200 enrolled1 locationNCT06118554
Recruiting
Phase 2

Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis

Chronic Rhinosinusitis (Diagnosis)
University of Illinois at Chicago60 enrolled1 locationNCT05427695
Recruiting
Phase 3

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Chronic Rhinosinusitis With Nasal Polyps
Sanofi210 enrolled112 locationsNCT06834360
Recruiting

Sinus Disease in Young Children With Cystic Fibrosis

Cystic FibrosisChronic Rhinosinusitis (Diagnosis)Olfactory Impairment+2 more
University of California, Los Angeles80 enrolled6 locationsNCT06191640
Recruiting
Not Applicable

Polysomnographic Findings in Nasal Polyposis

Obstructive Sleep ApneaChronic Rhinosinusitis With Nasal Polyps
University Hospital, Lille30 enrolled1 locationNCT03725956
Recruiting
Phase 3

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Chronic Rhinosinusitis With Nasal Polyps
Sanofi210 enrolled121 locationsNCT06834347
Recruiting
Phase 2

Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

Chronic Rhinosinusitis With Nasal Polyps
Sanofi64 enrolled24 locationsNCT06914908
Recruiting
Not Applicable

Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Cliniques universitaires Saint-Luc- Université Catholique de Louvain140 enrolled1 locationNCT06776042
Recruiting
Early Phase 1

Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis

Chronic Rhinosinusitis (Diagnosis)
University of Alabama at Birmingham20 enrolled1 locationNCT03439865
Recruiting

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

Cystic FibrosisChronic Rhinosinusitis (Diagnosis)
University of California, Los Angeles170 enrolled9 locationsNCT04469439
Recruiting
Phase 3

A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

Chronic Rhinosinusitis With Nasal Polyps
AstraZeneca180 enrolled45 locationsNCT06706817
Recruiting

Propel Drug-Eluting Sinus Implant Family IBUKI Cohort

Chronic Rhinosinusitis (CRS)
Medtronic100 enrolled1 locationNCT07546682