Chronic rhinosinusitis Clinical Trials

52 recruitingLast updated: May 11, 2026

There are 52 actively recruiting chronic rhinosinusitis clinical trials across 35 countries. Studies span Not Applicable, Phase 3, Phase 2, Phase 4, Early Phase 1, Phase 1. Top locations include Chicago, Illinois, United States, Ghent, Belgium, Leuven, Belgium. Updated daily from ClinicalTrials.gov.


Chronic rhinosinusitis Trials at a Glance

52 actively recruiting trials for chronic rhinosinusitis are listed on ClinicalTrialsFinder across 6 cities in 35 countries. The largest study group is Not Applicable with 10 trials, with the heaviest enrollment activity in Chicago, Ghent, and Leuven. Lead sponsors running chronic rhinosinusitis studies include AstraZeneca, Sanofi, and Medical University of Vienna.

Browse chronic rhinosinusitis trials by phase

Treatments under study

About Chronic rhinosinusitis Clinical Trials

Looking for clinical trials for Chronic rhinosinusitis? There are currently 21 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic rhinosinusitis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic rhinosinusitis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 52 trials

Recruiting

ReAl-woRld Evaluation of tEzepelumab for Chronic rhinoSinusitis With Nasal Polyps in Russia

AsthmaChronic Rhinosinusitis With Nasal Polyps (CRSwNP)
AstraZeneca110 enrolled9 locationsNCT07399665
Recruiting
Not Applicable

Polysomnographic Findings in Nasal Polyposis

Obstructive Sleep ApneaChronic Rhinosinusitis With Nasal Polyps
University Hospital, Lille30 enrolled1 locationNCT03725956
Recruiting
Phase 2

Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

Chronic Rhinosinusitis With Nasal Polyps
Sanofi64 enrolled24 locationsNCT06914908
Recruiting
Phase 3

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Chronic Rhinosinusitis With Nasal Polyps
Sanofi210 enrolled121 locationsNCT06834347
Recruiting
Not Applicable

Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Cliniques universitaires Saint-Luc- Université Catholique de Louvain140 enrolled1 locationNCT06776042
Recruiting
Phase 3

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Chronic Rhinosinusitis With Nasal Polyps
Sanofi210 enrolled113 locationsNCT06834360
Recruiting
Early Phase 1

Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis

Chronic Rhinosinusitis (Diagnosis)
University of Alabama at Birmingham20 enrolled1 locationNCT03439865
Recruiting
Phase 3

A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Eli Lilly and Company510 enrolled194 locationsNCT06338995
Recruiting

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

Cystic FibrosisChronic Rhinosinusitis (Diagnosis)
University of California, Los Angeles170 enrolled9 locationsNCT04469439
Recruiting

A Study to Investigate the Clinical Outcome and Quality of Life in Chinese Post-operative CRSwNP Patients

Chronic Rhinosinusitis With Nasal Polyps
AstraZeneca200 enrolled10 locationsNCT07446738
Recruiting
Phase 3

A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

Chronic Rhinosinusitis With Nasal Polyps
AstraZeneca180 enrolled45 locationsNCT06706817
Recruiting

Propel Drug-Eluting Sinus Implant Family IBUKI Cohort

Chronic Rhinosinusitis (CRS)
Medtronic100 enrolled1 locationNCT07546682
Recruiting
Not Applicable

Efficacy and Safety of Fully Resorbable Sinus Drug-eluting Stents in Patients With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps After Surgery: A Prospective, Randomized Controlled Trial

Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Tang-Du Hospital192 enrolled1 locationNCT07498374
Recruiting
Phase 3

Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps

Chronic Rhinosinusitis Without Nasal Polyps
Optinose US Inc.84 enrolled21 locationsNCT06850805
Recruiting
Phase 2

Long-term Safety and Efficacy of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps

Chronic rhinosinusitis
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.120 enrolled28 locationsNCT06439381
Recruiting

Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis

Chronic Rhinosinusitis With Nasal Polyps
Montefiore Medical Center60 enrolled1 locationNCT05246267
Recruiting
Early Phase 1

The Role of IL5 in Epithelial Cell Integrity

Chronic Rhinosinusitis With Nasal PolypsChronic Rhinosinusitis (Diagnosis)
Johns Hopkins University8 enrolled2 locationsNCT05895929
Recruiting
Phase 2

Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis

Postoperative CareChronic rhinosinusitis
Taichung Veterans General Hospital80 enrolled1 locationNCT07340411
Recruiting
Not Applicable

Real-Time Diagnosis of Eosinophilic Nasal Polyps Using High-Sensitivity Spectroscopy

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
The Affiliated Hospital of Qingdao University353 enrolled1 locationNCT07125586
Recruiting
Phase 3

Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

Chronic Rhinosinusitis (CRS)Cystic Fibrosis (CF)
Indiana University64 enrolled1 locationNCT06996951