Phase 1 Cognitive Impairment Clinical Trials
18 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–18 of 18 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
Cognitive ImpairmentSickle Cell DiseaseExecutive Dysfunction
St. Jude Children's Research Hospital72 enrolled1 locationNCT07226219
Recruiting
Phase 1Phase 2
rTMS to Improve Cognition in Parkinson's
Mild Cognitive ImpairmentParkinson's Disease
VA Office of Research and Development56 enrolled2 locationsNCT03836950
Recruiting
Phase 1Phase 2
Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
Alzheimer DiseaseMild Cognitive Impairment (MCI)Subjective Cognitive Complaints (SCCs)
Massachusetts General Hospital40 enrolled1 locationNCT07236190
Recruiting
Phase 1Phase 2
Sense4Safety Intervention
Mild Cognitive Impairment
University of Pennsylvania200 enrolled1 locationNCT07220668
Recruiting
Phase 1
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive Impairment
University of California, San Diego60 enrolled1 locationNCT06548191
Recruiting
Phase 1Phase 2
The Efficacy and Safety of Metformin Intervention in Elderly Overweight or Obesity With Mild Cognitive Impairment
ElderlyMild Cognitive ImpairmentOverweight or Obesity
Fudan University54 enrolled1 locationNCT07395960
Recruiting
Phase 1Phase 2
Living Independence Through Functional Training
Cognitive ImpairmentMobility Limitation
University of Florida10 enrolled2 locationsNCT07125378
Recruiting
Phase 1
Innate Immunity Stimulation Via TLR9 in Early AD
Mild Cognitive ImpairmentAlzheimer Dementia
NYU Langone Health18 enrolled1 locationNCT05606341
Recruiting
Phase 1
Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study
Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)
National University Hospital, Singapore48 enrolled1 locationNCT07210528
Recruiting
Phase 1
Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants
Alzheimer DiseaseMild Cognitive Impairment
Novartis Pharmaceuticals36 enrolled10 locationsNCT05469360
Recruiting
Phase 1Phase 2
Induced Pluripotent Stem Cells-derived Small Extracellular Vesicles May Promote Neurological Function and Improve Cognitive Impairment in Acute Ischemic Stroke Patients
Cognitive Impairment
Hongmei Wang40 enrolled1 locationNCT07145294
Recruiting
Phase 1
Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD
Alzheimer Disease, Early OnsetMild Cognitive ImpairmentModerate Dementia
Butler Hospital35 enrolled2 locationsNCT04500847
Recruiting
Phase 1
Safety and Target Engagement of Centella Asiatica in Cognitive Impairment
Mild Cognitive Impairment
Oregon Health and Science University48 enrolled1 locationNCT05591027
Recruiting
Phase 1
CogT pSOPT Intervention Study
Mild Cognitive ImpairmentSubjective Cognitive Impairment
Stanford University50 enrolled1 locationNCT06005038
Terminated
Phase 1
A Phase 1 Study to Evaluate the Safety, Pharmacokinetic (PK) and Effects of CST-2032 in Healthy Volunteers and Subjects with Mild Cognitive Impairment or Parkinson’s Disease
Mild Cognitive Impairment
CuraSen Therapeutics, Inc.118 enrolled2 locationsACTRN12620000957998
Not Yet Recruiting
Phase 1
An Imaging Study to Determine Changes in Brain Glucose Metabolism and Cerebral Blood Flow after Single-Dose of CST-101 in Healthy Subjects and Patients with Mild Cognitive Impairment
Mild Cognitive Impairment
CuraSen Therapeutics, Inc.16 enrolled1 locationACTRN12619000467134
Completed
Phase 1
Omega-3 fatty acids and mild cognitive impairment in older adults
Mild cognitive impairment in older adultsDepression
Nutritional Physiology Research Centre120 enrolled1 locationACTRN12609000167268