Phase 4 Depression Clinical Trials

54 recruitingPhase 4

What is a Phase 4 trial?

Phase 4 trials, also called post-marketing studies, are conducted after a treatment has been approved and is available to the public. They monitor long-term effectiveness and safety in a broader population.

Showing 120 of 54 trials

Recruiting
Phase 4

Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum Depression

Postpartum Depression (PPD)
Assistance Publique - Hôpitaux de Paris2,860 enrolled1 locationNCT06833788
Recruiting
Phase 4

Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression

Treatment Resistant Depression
The George Institute162 enrolled7 locationsNCT06278779
Recruiting
Phase 4

Identifying and Treating Depression in the Orthopaedic Trauma Population

Depression
Wake Forest University Health Sciences100 enrolled1 locationNCT05976347
Recruiting
Phase 4

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

DepressionBrain Injuries, Traumatic
Massachusetts General Hospital10 enrolled2 locationsNCT04400266
Recruiting
Phase 4

Establishing Mobile Transcranial Magnetic Stimulation

Treatment Resistant Major Depression
Medical University of South Carolina30 enrolled1 locationNCT06748209
Recruiting
Phase 4

Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant

DepressionAnxietyPsoriasis
Cairo University40 enrolled1 locationNCT07432815
Recruiting
Phase 4

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

DepressionAnhedoniaPsychosis
University of North Carolina, Chapel Hill103 enrolled1 locationNCT05282277
Recruiting
Phase 4

Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression

Major Depressive DisorderChronic Major Depression, Recurrent
University of Texas at Austin50 enrolled1 locationNCT05892744
Recruiting
Phase 4

Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression

Treatment Resistant Depression (TRD)
Aalborg University Hospital80 enrolled1 locationNCT07080723
Recruiting
Phase 4

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

Opioid UsePostoperative PainDepression+2 more
Texas Tech University Health Sciences Center90 enrolled2 locationsNCT06903819
Recruiting
Phase 4

TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children

Depression - Major Depressive DisorderDepressive Episodes
Poznan University of Medical Sciences180 enrolled1 locationNCT07478796
Recruiting
Phase 4

Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures

Depression in Old AgeFragility Fracture
Wake Forest University Health Sciences100 enrolled1 locationNCT05851898
Recruiting
Phase 4

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

Unipolar DepressionBipolar Depression
Mayo Clinic120 enrolled1 locationNCT07266545
Recruiting
Phase 4

Dopaminergic Therapy for Anhedonia - 2

DepressionAnhedonia
Emory University70 enrolled1 locationNCT06075771
Recruiting
Phase 4

Esketamine With or Without Integration Therapy for Treatment-Resistant Depression

Treatment Resistant Depression (TRD)
University of Puerto Rico20 enrolled2 locationsNCT07369102
Recruiting
Phase 4

Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9)

Depression Bipolar
Aalborg University Hospital122 enrolled1 locationNCT05913947
Recruiting
Phase 4

Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia

DepressionAnxietyFunctional Dyspepsia+1 more
Xijing Hospital of Digestive Diseases180 enrolled1 locationNCT07182890
Recruiting
Phase 4

Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia

DepressionAnxietyFunctional Dyspepsia+1 more
Xijing Hospital of Digestive Diseases180 enrolled1 locationNCT07187492
Recruiting
Phase 4

Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burst Stimulation (iTBS) in Patients With Depression

Depression - Major Depressive DisorderDepression Bipolar
Region Örebro County350 enrolled2 locationsNCT07026461
Not Yet Recruiting
Phase 4

Immune Effects of Respiratory Syncytial Virus (RSV) Vaccination in Older Adults

Response to vaccinationDepressionStress+1 more
Tasmanian Health Service120 enrolled1 locationACTRN12625001211459