Phase 2 Depression Clinical Trials
115 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 115 trials
Recruiting
Phase 2
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
DepressionDepressive DisorderMolecular Mechanisms of Pharmacological Action+10 more
National Institute of Mental Health (NIMH)50 enrolled1 locationNCT06511908
Recruiting
Phase 2
Neurobiology of Suicide
DepressionHealthy Volunteers
National Institute of Mental Health (NIMH)325 enrolled1 locationNCT02543983
Recruiting
Phase 2
Cannabidiol and Older Adult Cannabis Users
PainDepressionSleep+1 more
University of Colorado, Boulder385 enrolled1 locationNCT06290063
Recruiting
Phase 2
Mindfulness-based Psilocybin Therapy for PTSD
Depression - Major Depressive DisorderPost Traumatic Stress Disorder
Anthony P King30 enrolled1 locationNCT07104916
Recruiting
Phase 2
Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients
Depression DisorderKetamine
Hospital Italiano de Buenos Aires50 enrolled2 locationsNCT07639359
Recruiting
Phase 2
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
DepressionMajor Depressive Disorder (MDD)Major Depressive Episode (MDE)
Tonix Pharmaceuticals, Inc.360 enrolled25 locationsNCT07621237
Recruiting
Phase 2
Psilocybin Therapy for Depression in Parkinson's Disease
DepressionParkinson Disease
Joshua Woolley, MD, PhD60 enrolled1 locationNCT06455293
Recruiting
Phase 2
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
Treatment Resistant Depression
Centre for Addiction and Mental Health12 enrolled1 locationNCT06512220
Recruiting
Phase 2
Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies
Hematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid NeoplasmDepression+1 more
University of Washington18 enrolled1 locationNCT07336238
Recruiting
Phase 2
Inflammation and Depression in People With HIV
DepressionAnhedoniaHIV
Emory University60 enrolled2 locationsNCT05849038
Recruiting
Phase 2
Inhaled DMT for Major Depressive Disorder
SuicideSuicidal IdeationMajor Depression+2 more
Universidade Federal do Rio Grande do Norte140 enrolled5 locationsNCT07562191
Recruiting
Phase 2
An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression
Treatment Resistant Depression
Beckley Psytech Limited64 enrolled3 locationsNCT05660642
Recruiting
Phase 2
Stratified Pharmacological Approaches for Regulating Circuit-Level Effects
Depression - Major Depressive Disorder
Stanford University60 enrolled1 locationNCT07022405
Recruiting
Phase 2
Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer
Lung Non-Small Cell CarcinomaUnipolar Depression
Alan Davis10 enrolled1 locationNCT07216404
Recruiting
Phase 2
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
Treatment Resistant Depression
atai Therapeutics, Inc.142 enrolled48 locationsNCT06524830
Recruiting
Phase 2
Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease
DepressionParkinson DiseasePARKINSON DISEASE (Disorder)
University of British Columbia60 enrolled1 locationNCT05568498
Recruiting
Phase 2
Modulating Exercise Dosage to Improve Concussion Recovery
TreatmentDepression, AnxietyAerobic Exercise+2 more
University of Colorado, Denver216 enrolled3 locationsNCT05434130
Recruiting
Phase 2
Training Reward Responsiveness Through Virtual Reality
DepressionPositive Affect
University of California, Los Angeles80 enrolled1 locationNCT07219875
Recruiting
Phase 2
Mindfulness Engaged Neurostimulation for Depression (MEND II)
DepressionDepressive DisorderDepressive Symptoms+2 more
University of California, San Diego120 enrolled1 locationNCT07512284
Recruiting
Phase 1Phase 2
Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease
Quality of LifeDepression, AnxietyStress Reaction+1 more
Children's Hospital Los Angeles66 enrolled1 locationNCT05685368