Metastases Clinical Trials

338 recruitingLast updated: June 17, 2026

There are 338 actively recruiting metastases clinical trials across 46 countries. Studies span Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Houston, Texas, United States, New York, New York, United States, Guangzhou, Guangdong, China. Updated daily from ClinicalTrials.gov.


Metastases Trials at a Glance

338 actively recruiting trials for metastases are listed on ClinicalTrialsFinder across 6 cities in 46 countries. The largest study group is Phase 2 with 113 trials, with the heaviest enrollment activity in Houston, New York, and Guangzhou. Lead sponsors running metastases studies include M.D. Anderson Cancer Center, Fudan University, and Memorial Sloan Kettering Cancer Center.

Treatments under study

About Metastases Clinical Trials

Looking for clinical trials for Metastases? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Metastases trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Metastases clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 338 trials

Recruiting
Phase 1Phase 2

Safety of HRX215 in Patients After Minor and Major Liver Resection

Liver ResectionColorectal Carcinoma Liver Metastases
HepaRegeniX GmbH80 enrolled6 locationsNCT06638502
Recruiting

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

Thoracic CancersLung Cancer NOSMalignant Pleural Mesotheliomas NOS+2 more
National Cancer Institute (NCI)1,559 enrolled1 locationNCT00242723
Recruiting
Phase 2

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

CancerBrain Metastases, AdultNeurocognitive Function
Jona Hattangadi-Gluth60 enrolled1 locationNCT04343157
Recruiting
Phase 2

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Lung CancerBrain Metastases, AdultBrain Metastases+3 more
Memorial Sloan Kettering Cancer Center62 enrolled7 locationsNCT05419076
Recruiting
Not Applicable

OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases

Liver MetastasesStereotactic Body Radiation TherapyMRI-guided Treatment
University of Wisconsin, Madison32 enrolled1 locationNCT04020276
Recruiting
Phase 1

Safety and Efficacy of NRT6008 in Patients With Unresectable Locally Advanced Pancreatic Cancer (LAPC) and Advanced Pancreatic Cancer With Lymph Node Metastases

Lymph Node MetastasesUnresectable Pancreatic CancerAdvanced Pancreatic Cancer
Chengdu New Radiomedicine Technology Co. LTD.58 enrolled6 locationsNCT06278454
Recruiting
Phase 3

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Brain Metastases
Canadian Cancer Trials Group206 enrolled86 locationsNCT03550391
Recruiting

FOLFIRINOX Induction Chemotherapy for Synchronous Liver Metastases

Antineoplastic Combined Chemotherapy ProtocolsRectal CancerSynchronous Liver Metastases+1 more
Assistance Publique - Hôpitaux de Paris550 enrolled1 locationNCT07467434
Recruiting
Phase 2

Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases

Spine MetastasesSpine Stereotactic Radiosurgery (sSRS)
Case Comprehensive Cancer Center130 enrolled1 locationNCT04218617
Recruiting
Not Applicable

Proton Therapy in the Treatment of Liver Metastases

Liver Metastases
Loma Linda University35 enrolled1 locationNCT01697371
Recruiting
Phase 1

A Phase 1/1b Study of IAM1363 in HER2 Cancers

HER2-positive Breast CancerHER2 + Breast CancerHER2 Mutation-Related Tumors+10 more
Iambic Therapeutics, Inc383 enrolled53 locationsNCT06253871
Recruiting

Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy.

Brain MetastasesRadiation NecrosisShort Time Examination
Centre Hospitalier Universitaire, Amiens50 enrolled1 locationNCT07632092
Recruiting
Not Applicable

Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases

Spinal cord compressionSpine MetastasesNeoplasm Metastasis+2 more
Henry Ford Health System60 enrolled1 locationNCT05023772
Recruiting
Phase 2

Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas

Neoplasm MetastasesMetastases, Neoplasm
Rutgers, The State University of New Jersey124 enrolled7 locationsNCT05419518
Recruiting
Phase 1Phase 2

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

Metastatic MelanomaLiver Metastases
University of Wisconsin, Madison15 enrolled1 locationNCT07281924
Recruiting
Phase 2

INTERACT Stomach-II

Peritoneal Metastases From Gastric Cancer
Erasmus Medical Center55 enrolled3 locationsNCT07133490
Recruiting
Phase 3

Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung

Lung CancerLung Metastases
Vergent Bioscience, Inc.132 enrolled9 locationsNCT07499674
Recruiting
Not Applicable

MeDex: No Perioperative Dexamethasone in Brain Metastases

Brain Metastases
University of Louisville35 enrolled1 locationNCT07044557
Recruiting
Phase 1

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

Advanced Malignancies With Homologous Recombination Deficiency (HRD) (Breast, Ovarian, mCRPC, Brain Metastases)
Duke Street Bio Ltd180 enrolled15 locationsNCT06458712
Recruiting

Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery

Breast CancerNode-positive Breast CancerSentinel Lymph Node Biopsy (SLNB)+4 more
University Hospitals of Derby and Burton NHS Foundation Trust300 enrolled12 locationsNCT07085442