Brain Injury Clinical Trials

339 recruitingLast updated: June 18, 2026

There are 339 actively recruiting brain injury clinical trials across 41 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4, Early Phase 1. Top locations include Minneapolis, Minnesota, United States, Boston, Massachusetts, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Brain Injury Trials at a Glance

339 actively recruiting trials for brain injury are listed on ClinicalTrialsFinder across 6 cities in 41 countries. The largest study group is Not Applicable with 164 trials, with the heaviest enrollment activity in Minneapolis, Boston, and Dallas. Lead sponsors running brain injury studies include VA Office of Research and Development, Rigshospitalet, Denmark, and Kessler Foundation.

Browse brain injury trials by phase

Treatments under study

About Brain Injury Clinical Trials

Looking for clinical trials for Brain Injury? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Brain Injury trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Brain Injury clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 339 trials

Recruiting
Not Applicable

Promoting Recovery After Brain Injury Using Focused Ultrasound

Consciousness DisordersDisorders of Consciousness Due to Severe Brain Injury
Massachusetts General Hospital36 enrolled2 locationsNCT07277309
Recruiting
Not Applicable

Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury

AlexithymiaMild Traumatic Brain Injury
Hackensack Meridian Health300 enrolled3 locationsNCT07436754
Recruiting
Not Applicable

Regulating Emotions and Behaviors After Brain Injury

EncephalitisAcquired Brain InjuryMeningitis+3 more
University Hospital, Strasbourg, France77 enrolled1 locationNCT05393492
Recruiting

fNIRS for Disorders of Consciousness

comaBrain InjuryDisorders of Consciousness+4 more
University of California, Los Angeles55 enrolled1 locationNCT07485361
Recruiting
Not Applicable

Home-based Vision Rehabilitation Guided by Brain Imaging

Traumatic Brain InjuryBrain TumorStroke+6 more
Georgetown University100 enrolled1 locationNCT07635329
Recruiting
Not Applicable

Early Neuromodulation in Traumatic Brain Injury

Traumatic Brain Injury (TBI) Patients
University of Cincinnati60 enrolled1 locationNCT06871124
Recruiting
Phase 2

Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial

Acute brain injuryTraumatic Brain InjuryNeurocritical Care+1 more
Erasme University Hospital88 enrolled3 locationsNCT07625995
Recruiting

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Traumatic Brain Injury
Hoffmann-La Roche2,000 enrolled13 locationsNCT07455136
Recruiting
Not Applicable

REhabilitation of MEMory Symptoms After BRain Concussion

Mild Traumatic Brain InjuryConcussion, Brain
University of British Columbia184 enrolled8 locationsNCT06956417
Recruiting
Phase 2

Hyperbaric Oxygen Brain Injury Treatment Trial

Traumatic Brain Injury
Gaylan Rockswold200 enrolled11 locationsNCT02407028
Recruiting
Not Applicable

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

InsomniaTraumatic Brain InjuryDepression+7 more
Johns Hopkins University360 enrolled5 locationsNCT05663034
Recruiting
Not Applicable

Effect of Fixation Training With Colored Light Targets on Traumatic Brain Injury-Associated Photophobia

Traumatic Brain Injury (TBI) Patients
Ohio State University20 enrolled1 locationNCT07606300
Recruiting
Not Applicable

Facilitating Access to Specialty Treatment

Mild Traumatic Brain InjuryConcussion, MildConcussion, Intermediate+1 more
Children's Hospital of Philadelphia210 enrolled1 locationNCT05741411
Recruiting

Stimulus Equivalence Learning in Acquired Brain Injury.

Acquired Brain Injury (Including Stroke)
Klimmendaal Revalidatiespecialisten40 enrolled1 locationNCT07345481
Recruiting
Not Applicable

Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury

Traumatic Brain Injury
University of New Mexico108 enrolled5 locationsNCT05236010
Recruiting
Not Applicable

Ultrasound Stimulation for Patients in a Disorder of Consciousness

Consciousness DisordersDisorders of Consciousness Due to Severe Brain Injury
University of California, Los Angeles60 enrolled4 locationsNCT06939348
Recruiting
Not Applicable

Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation

Traumatic Brain InjuryPost Traumatic Stress Disorder
Florida State University132 enrolled1 locationNCT06544408
Recruiting
Not Applicable

Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure

Neonatal Brain Injuryperinatal morbidityMechanical Ventilation+10 more
Medical College of Wisconsin320 enrolled1 locationNCT07274527
Recruiting
Phase 3

Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)

Mild Traumatic Brain InjuryAdult Growth Hormone Deficiency
VA Office of Research and Development172 enrolled17 locationsNCT04867317
Recruiting
Early Phase 1

Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System

Traumatic Brain Injury
Virginia Commonwealth University126 enrolled1 locationNCT06188364