Phase 1 HIV Clinical Trials
35 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 35 trials
Recruiting
Phase 1
A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV
HIV-1-infection
BioNTech SE61 enrolled3 locationsNCT07392372
Recruiting
Phase 1
First Time in Human Study of Long Acting VH4524184 Formulations
HIV Infections
ViiV Healthcare268 enrolled2 locationsNCT06310551
Recruiting
Phase 1
Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Newborns Exposed to HIV
HIV-1-infection
Gilead Sciences16 enrolled7 locationsNCT07055451
Recruiting
Phase 1
MK-4646 Multiple Dose Trial in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) (MK-4646-003)
HIV Infection
Merck Sharp & Dohme LLC28 enrolled2 locationsNCT07042945
Recruiting
Phase 1
The Efficacy and Safety Study of CAR-T Cells for Functional Cure in HIV-1/AIDS Patients
HIVHIV Infected Individuals
Institute of Hematology & Blood Diseases Hospital, China3 enrolled1 locationNCT06880380
Recruiting
Phase 1Phase 2
Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...
Hematologic MalignanciesHIV
National Cancer Institute (NCI)265 enrolled1 locationNCT05470491
Recruiting
Phase 1Phase 2
Exploratory Study of LP-98 for Injection in ART-Naive HIV-Infected Individuals
HIV
Shanxi Kangbao Biological Product Co., Ltd.30 enrolled1 locationNCT07433387
Recruiting
Phase 1
Safety and Immunogenicity Study of Three mRNAs Encoding HIV Immunogens in Adult Participants Without HIV and in Overall Good Health in South Africa.
HIV Infections
International AIDS Vaccine Initiative96 enrolled6 locationsNCT06694753
Recruiting
Phase 1Phase 2
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
HIVNon-HIVVagus Nerve Dysfunction
Icahn School of Medicine at Mount Sinai207 enrolled1 locationNCT04353778
Recruiting
Phase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)40 enrolled7 locationsNCT06665646
Recruiting
Phase 1
Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers
Healthy VolunteerHIV Prevention
Johns Hopkins University24 enrolled1 locationNCT07349758
Recruiting
Phase 1
A Trial of a Gorilla Adenovirus Vectored Networked Epitopes Vaccine, Administered to Healthy Adults Living Without and With HIV.
HIV
International AIDS Vaccine Initiative120 enrolled3 locationsNCT06617091
Recruiting
Phase 1
Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
HIV InfectionRecurrent Non-Hodgkin LymphomaRefractory Non-Hodgkin Lymphoma+12 more
AIDS Malignancy Consortium20 enrolled5 locationsNCT05077527
Recruiting
Phase 1Phase 2
Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1
HIV-1-infection
National Institute of Allergy and Infectious Diseases (NIAID)36 enrolled12 locationsNCT06071767
Recruiting
Phase 1
Safety Study of MucoCept-CVN
HIV-1-infection
Craig Cohen, MD, MPH12 enrolled1 locationNCT07181486
Recruiting
Phase 1
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
Cannabis UseAlcohol DrinkingHIV+1 more
Yale University100 enrolled1 locationNCT06513819
Recruiting
Phase 1
A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV
HIV Infections
ViiV Healthcare100 enrolled41 locationsNCT07053384
Recruiting
Phase 1Phase 2
Low Dose Nivolumab in Adults Living With HIV on Antiretroviral Therapy
HIV I Infection
University of Melbourne42 enrolled2 locationsNCT05187429
Recruiting
Phase 1
A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants
HIV Infections
ViiV Healthcare214 enrolled3 locationsNCT05418868
Recruiting
Phase 1
The DART DELIVER-02 Study
HIV (Human Immunodeficiency Virus)
University of North Carolina, Chapel Hill24 enrolled3 locationsNCT07217379