Phase 1 HIV Clinical Trials
44 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 44 trials
Recruiting
Phase 1Phase 2
Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...
Hematologic MalignanciesHIV
National Cancer Institute (NCI)265 enrolled1 locationNCT05470491
Recruiting
Phase 1
MK-4646 Multiple Dose Trial in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) (MK-4646-003)
HIV Infection
Merck Sharp & Dohme LLC28 enrolled2 locationsNCT07042945
Recruiting
Phase 1Phase 2
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)1,120 enrolled46 locationsNCT02140255
Recruiting
Phase 1
A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1
HIV
National Institute of Allergy and Infectious Diseases (NIAID)83 enrolled12 locationsNCT07390955
Recruiting
Phase 1Phase 2
Exploratory Study of LP-98 for Injection in ART-Naive HIV-Infected Individuals
HIV
Shanxi Kangbao Biological Product Co., Ltd.30 enrolled1 locationNCT07433387
Recruiting
Phase 1Phase 2
Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age
HIV-1-infection
National Institute of Allergy and Infectious Diseases (NIAID)90 enrolled12 locationsNCT05660980
Recruiting
Phase 1
First Time in Human Study of Long Acting VH4524184 Formulations
HIV Infections
ViiV Healthcare268 enrolled3 locationsNCT06310551
Recruiting
Phase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)40 enrolled7 locationsNCT06665646
Recruiting
Phase 1
Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
HIV InfectionRecurrent Non-Hodgkin LymphomaRefractory Non-Hodgkin Lymphoma+11 more
AIDS Malignancy Consortium20 enrolled6 locationsNCT05077527
Recruiting
Phase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV
HIV
National Institute of Allergy and Infectious Diseases (NIAID)40 enrolled7 locationsNCT07390474
Recruiting
Phase 1Phase 2
CAR-T Cells for HIV Infection
HIV Infections
Steven Deeks18 enrolled2 locationsNCT04648046
Recruiting
Phase 1
Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1
HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)48 enrolled17 locationsNCT06517693
Recruiting
Phase 1
Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Newborns Exposed to HIV
HIV-1-infection
Gilead Sciences16 enrolled7 locationsNCT07055451
Recruiting
Phase 1
Study of GS-3242 in Participants With HIV-1; Substudy-05
HIV-1-infection
Gilead Sciences30 enrolled28 locationsNCT07001319
Recruiting
Phase 1
The Efficacy and Safety Study of CAR-T Cells for Functional Cure in HIV-1/AIDS Patients
HIVHIV Infected Individuals
Institute of Hematology & Blood Diseases Hospital, China3 enrolled1 locationNCT06880380
Recruiting
Phase 1
Safety and Immunogenicity Study of Three mRNAs Encoding HIV Immunogens in Adult Participants Without HIV and in Overall Good Health in South Africa.
HIV Infections
International AIDS Vaccine Initiative96 enrolled6 locationsNCT06694753
Recruiting
Phase 1Phase 2
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
HIVNon-HIVVagus Nerve Dysfunction
Icahn School of Medicine at Mount Sinai207 enrolled1 locationNCT04353778
Recruiting
Phase 1
Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers
Healthy VolunteerHIV Prevention
Johns Hopkins University24 enrolled1 locationNCT07349758
Recruiting
Phase 1
A Trial of a Gorilla Adenovirus Vectored Networked Epitopes Vaccine, Administered to Healthy Adults Living Without and With HIV.
HIV
International AIDS Vaccine Initiative120 enrolled3 locationsNCT06617091
Recruiting
Phase 1Phase 2
Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1
HIV-1-infection
National Institute of Allergy and Infectious Diseases (NIAID)36 enrolled12 locationsNCT06071767