Progressive Aphasia Clinical Trials

25 recruitingLast updated: June 18, 2026

There are 25 actively recruiting progressive aphasia clinical trials across 6 countries. Studies span Not Applicable, Phase 2, Early Phase 1, Phase 4. Top locations include Philadelphia, Pennsylvania, United States, Rochester, Minnesota, United States, Baltimore, Maryland, United States. Updated daily from ClinicalTrials.gov.


Progressive Aphasia Trials at a Glance

25 actively recruiting trials for progressive aphasia are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Philadelphia, Rochester, and Baltimore. Lead sponsors running progressive aphasia studies include Johns Hopkins University, Mayo Clinic, and Maya Henry.

Browse progressive aphasia trials by phase

Treatments under study

About Progressive Aphasia Clinical Trials

Looking for clinical trials for Progressive Aphasia? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Progressive Aphasia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Progressive Aphasia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 25 trials

Recruiting
Not Applicable

Stimulating the Aging Brain Using Brain and Sensory Stimulation

Primary Progressive Aphasia
Medical College of Wisconsin20 enrolled1 locationNCT07650188
Recruiting
Not Applicable

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

DementiaAlzheimer DiseaseCommunication Disorders+11 more
Stephanie Grasso60 enrolled3 locationsNCT05741853
Recruiting
Early Phase 1

Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

DementiaAlzheimer DiseaseProgressive Aphasia+3 more
University of Texas at Austin120 enrolled1 locationNCT06511752
Recruiting
Phase 2

Communication Bridge 3 Study

Primary Progressive Aphasia
University of Chicago200 enrolled1 locationNCT06191198
Recruiting
Early Phase 1

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

Alzheimer DiseaseMild Cognitive ImpairmentLogopenic Progressive Aphasia+1 more
Massachusetts General Hospital30 enrolled1 locationNCT06538311
Recruiting
Not Applicable

Remotely-supervised Neuromodulation in PPA

Primary Progressive Aphasia(PPA)Progressive AphasiaProgressive Aphasia in Alzheimer's Disease+3 more
Maya Henry80 enrolled2 locationsNCT07260253
Recruiting
Phase 2

Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

Primary Progressive AphasiaLogopenic Progressive AphasiaNon-Fluent Primary Progressive Aphasia
Johns Hopkins University180 enrolled3 locationsNCT05386394
Recruiting

The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech

Apraxia of SpeechPrimary Progressive AphasiaNon-fluent Aphasia+1 more
Mayo Clinic47 enrolled1 locationNCT03313011
Recruiting
Phase 2

Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia

Nonfluent Variant Primary Progressive Aphasia (nfvPPA)
EIP Pharma Inc20 enrolled7 locationsNCT07033481
Recruiting
Not Applicable

Long Term Effect of Brain Stimulation in PPA

Primary Progressive Aphasia(PPA)
Hospital San Carlos, Madrid80 enrolled1 locationNCT07158216
Recruiting
Not Applicable

Intervention for Communication Quality of Life in Primary Progressive Aphasia

Primary Progressive Aphasia(PPA)Progressive AphasiaLogopenic Progressive Aphasia (LPA)+9 more
Maya Henry30 enrolled1 locationNCT07219680
Recruiting

Language in Primary Progressive Aphasia

Primary Progressive Aphasia
Northwestern University500 enrolled1 locationNCT00537004
Recruiting

Speech and Language Interventions for Italian People With PPA

Primary Progressive Aphasia(PPA)
Istituti Clinici Scientifici Maugeri SpA30 enrolled2 locationsNCT06739967
Recruiting

UPenn Observational Research Repository on Neurodegenerative Disease

Corticobasal Syndrome(CBS)Progressive Supranuclear Palsy (PSP)Primary Progressive Aphasia(PPA)+6 more
University of Pennsylvania1,000 enrolled1 locationNCT04715399
Recruiting

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

DementiaAlzheimer DiseaseParkinson Disease+7 more
University Health Network, Toronto500 enrolled4 locationsNCT06529744
Recruiting
Phase 4

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech

Apraxia of SpeechPrimary Progressive AphasiaPPA+2 more
Mayo Clinic50 enrolled1 locationNCT01818661
Recruiting
Not Applicable

STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners

Caregiver BurdenCorticobasal SyndromePrimary Progressive Aphasia(PPA)+1 more
Oregon Health and Science University640 enrolled1 locationNCT06613204
Recruiting
Not Applicable

Effects of Electrical Stimulation on Verbal Learning in Typical and Atypical Alzheimer's Disease

Alzheimer Disease, Early OnsetAtypical Alzheimer's DiseaseLogopenic Progressive Aphasia
Johns Hopkins University90 enrolled1 locationNCT04122001
Recruiting
Not Applicable

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

Primary Progressive AphasiaLogopenic Progressive Aphasia
Johns Hopkins University60 enrolled1 locationNCT03887481
Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Amyotrophic Lateral SclerosisCorticobasal Degeneration (CBD)Progressive Supranuclear Palsy (PSP)+11 more
Mayo Clinic2,100 enrolled27 locationsNCT04363684