ISS Clinical Trials

819 recruitingLast updated: July 26, 2026

There are 819 actively recruiting iss clinical trials across 80 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Houston, Texas, United States, New York, New York, United States, Philadelphia, Pennsylvania, United States. Updated daily from ClinicalTrials.gov.


ISS Trials at a Glance

819 actively recruiting trials for iss are listed on ClinicalTrialsFinder across 6 cities in 80 countries. The largest study group is Not Applicable with 321 trials, with the heaviest enrollment activity in Houston, New York, and Philadelphia. Lead sponsors running iss studies include Chinese University of Hong Kong, M.D. Anderson Cancer Center, and Assistance Publique - Hôpitaux de Paris.

Treatments under study

About ISS Clinical Trials

Looking for clinical trials for ISS? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new ISS trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about ISS clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 819 trials

Recruiting
Phase 3

PSMA PET Combined With MRI for the Detection of PCa

Prostate CancerProstatic NeoplasmPCA+6 more
Telix Pharmaceuticals (Innovations) Pty Limited338 enrolled18 locationsNCT07052214
Recruiting

Colorectal Resections in Patients With Retroperitoneal Sarcoma

Sarcoma,Soft TissueRetroperitoneal Sarcoma
Heidelberg University120 enrolled16 locationsNCT06943612
Recruiting
Phase 2

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, AXIOM Trial

Metastatic Alveolar Soft Part SarcomaAdvanced Soft Tissue SarcomaAdvanced Alveolar Soft Part Sarcoma+2 more
National Cancer Institute (NCI)27 enrolled13 locationsNCT05333458
Recruiting
Phase 2

Assessment of the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall

Soft Tissue Sarcoma AdultSoft Tissue Sarcoma (Excluding GIST)Soft Tissue Sarcoma of the Trunk and Extremities+1 more
Centre Oscar Lambret135 enrolled1 locationNCT07507773
Recruiting
Phase 2

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Sarcoma,Soft TissueSarcoma Metastatic
Wake Forest University Health Sciences50 enrolled2 locationsNCT07291297
Recruiting
Early Phase 1

68Ga-FAPI PET/CT in Patients With Various Types of Cancer

MetastasisTumorPositron Emission Tomography
First Affiliated Hospital of Fujian Medical University500 enrolled1 locationNCT04499365
Recruiting
Not Applicable

Application of 68Ga-Pentixafor PET/CT in Primary Aldosteronism and Pre-postoperative of SAAE

Positron Emission Tomography
First Affiliated Hospital of Fujian Medical University100 enrolled1 locationNCT05188872
Recruiting
Phase 1

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

Soft Tissue SarcomaMelanoma
University of Florida18 enrolled1 locationNCT05264974
Recruiting
Not Applicable

Evaluation of a Digital Pre-therapy Patient Education Program (StartHjelp) in Outpatient Mental Health Care

Mental Health IssuePatient EducationMental Disorder
St. Olavs Hospital170 enrolled1 locationNCT06212687
Recruiting
Not Applicable

Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

Rheumatoid ArthritisPsoriatic ArthritisSystemic Lupus Erythematosus+6 more
Terry L. Wahls400 enrolled1 locationNCT07180537
Recruiting
Not Applicable

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

MelanomaBreast Cancer, NOSCNS Primary Tumor, NOS+9 more
Eastern Cooperative Oncology Group400 enrolled347 locationsNCT05108298
Recruiting

Long-Term Follow up of Patients Undergoing Hematopoietic Stem Cell Transplantation, Cellular Therapy, or Gene Therapy

Hematopoietic Stem Cell TransplantationTissue DonorsCellular Immunotherapy, Adoptive+1 more
National Cancer Institute (NCI)2,000 enrolled1 locationNCT03000244
Recruiting

PregnAncy-Related Aortic DISsEction in China

Aortic DissectionMarfan SyndromeLoeys-Dietz Syndrome+3 more
DeltaHealth Hospital · Shanghai500 enrolled4 locationsNCT07672210
Recruiting

Natural History of Depression, Bipolar Disorder and Suicide Risk

Molecular Mechanisms of Pharmacological ActionDepressive SymptomsSuicide+18 more
National Institute of Mental Health (NIMH)500 enrolled1 locationNCT06462196
Recruiting
Phase 1

A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas

Soft Tissue Sarcomas
M.D. Anderson Cancer Center18 enrolled1 locationNCT07444619
Recruiting
Not Applicable

GORE® TAG® Thoracic Branch Endoprosthesis Zone 0/1 Post-Approval Study

Aortic Arch AneurysmAortic Arch Dissection
W.L.Gore & Associates125 enrolled12 locationsNCT07166133
Recruiting
Phase 1Phase 2

Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

Triple-Negative Breast CancerOvarian CancerCervical Cancer+3 more
University of California, Irvine67 enrolled1 locationNCT07064018
Recruiting
Phase 1

Actinium Therapy for Late-stage Aggressive Sarcomas

Advanced Soft Tissue Sarcoma
Ratio Therapeutics, Inc.30 enrolled6 locationsNCT07156565
Recruiting
Phase 1

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909
Recruiting
Phase 3

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Metastatic Dedifferentiated LiposarcomaStage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8+3 more
National Cancer Institute (NCI)365 enrolled257 locationsNCT06422806