ISS Clinical Trials

1 recruiting

ISS Trials at a Glance

699 actively recruiting trials for iss are listed on ClinicalTrialsFinder across 6 cities in 76 countries. The largest study group is Not Applicable with 273 trials, with the heaviest enrollment activity in Houston, New York, and Boston. Lead sponsors running iss studies include Mayo Clinic, Yale University, and Assistance Publique - Hôpitaux de Paris.

Treatments under study

About ISS Clinical Trials

Looking for clinical trials for ISS? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new ISS trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about ISS clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 699 trials

Recruiting
Phase 3

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Metastatic Dedifferentiated LiposarcomaStage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8+3 more
National Cancer Institute (NCI)365 enrolled248 locationsNCT06422806
Recruiting
Phase 3

Comparison of Weekly Somatrogon to Daily Genotropin in Children Born Small for Gestational Age or With Idiopathic Short Stature.

ISSSGA
Rabin Medical Center254 enrolled32 locationsNCT07226089
Recruiting
Not Applicable

IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

Type B Aortic Dissection
Duke University1,100 enrolled63 locationsNCT06087029
Recruiting

Natural History of Depression, Bipolar Disorder and Suicide Risk

Molecular Mechanisms of Pharmacological ActionDepressive SymptomsSuicide+17 more
National Institute of Mental Health (NIMH)500 enrolled1 locationNCT06462196
Recruiting

Association Between Exercise, Patient-Reported Outcomes, and Clinical Events in Adult Cancer Survivors

CancerSurvivorshipRecurrent+2 more
Memorial Sloan Kettering Cancer Center1,000 enrolled4 locationsNCT07030686
Recruiting

Long Term Clinical Outcome After Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue

AugmentationArthroscopic Rotator Cuff RepairMicrofragmented Adipose Tissue
University of Milan52 enrolled1 locationNCT06960343
Recruiting
Phase 2

Pemetrexed, Cisplatin With Soft Tissue Sarcoma

Sarcoma,Soft Tissue
Yonsei University164 enrolled1 locationNCT04605770
Recruiting
Phase 1

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

Soft Tissue SarcomaMelanoma
University of Florida18 enrolled1 locationNCT05264974
Recruiting
Not Applicable

Spatially Fractionated Radiotherapy Versus Conventional Radiotherapy in the Treatment of Soft Tissue Sarcoma

Soft Tissue Sarcoma (STS)
Shandong Cancer Hospital and Institute106 enrolled1 locationNCT06980259
Recruiting
Not Applicable

Pontic Site Development With or Without Fixed Partial Denture

Connective Tissue GraftKeratinized Tissue DeficiencyMucogingival Defects+1 more
Cairo University20 enrolled1 locationNCT07535060
Recruiting
Not Applicable

Assessment of Soft Tissue Thickness Following Utilization of Buccal Pad of Fat Versus Platelet-rich Fibrin for Covering Zygomatic Implants: A Randomized Clinical Trial

Soft Tissue Augmentation at Dental Implants
Cairo University24 enrolled1 locationNCT07562334
Recruiting
Not Applicable

Stanford Program to Accelerate Robotic Children's Surgery

EndometriosisCholecystectomyHysterectomy+16 more
Stanford University250 enrolled1 locationNCT06671639
Recruiting
Phase 4

Adjunctive Hyperbaric Oxygen Treatment for Patients With Necrotizing Soft-Tissue Infection (HOT-NSTI Trial).

Necrotizing Soft Tissue Infection
Ole Hyldegaard1,480 enrolled1 locationNCT07489274
Recruiting
Not Applicable

Post-Extraction Healing: microRepair vs Chlorhexidine

Endodontic IssuePeriodontal Issues
University of Roma La Sapienza30 enrolled1 locationNCT07555366
Recruiting
Not Applicable

ALND vs ART in Positive Sentinel Node After Neoadjuvant Therapy in Breast Cancer

Breast CancerRadiotherapy Side EffectSentinel Lymph Node+2 more
Hospital Universitari de Bellvitge820 enrolled60 locationsNCT04889924
Recruiting

Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility

Normal and Diseased Tissue and Body Fluids Samples
St. Jude Children's Research Hospital100,000 enrolled14 locationsNCT01354002
Recruiting

Cardiovascular Health Improvement Project

Heart FailureCardiovascular DiseasesAortic Aneurysm+2 more
University of Michigan15,000 enrolled1 locationNCT02306200
Recruiting
Not Applicable

Just-in-Time Training for Youth Mentors

DepressionMental Health IssueAnxiety
University of Minnesota204 enrolled1 locationNCT07129070
Recruiting

Galvanize Prospective/Retrospective Pulsed Electric Field Device Registry

Soft Tissue Lesion
Galvanize Therapeutics, Inc.1,000 enrolled10 locationsNCT05851430
Recruiting

Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment

Antibiotic Resistant StrainTransmission, Close-Contact
Assistance Publique - Hôpitaux de Paris525 enrolled1 locationNCT06262009